
I have always liked Luke Cage and Heroes for Hire but I have a rough time pinning down a villain as his Arch Nemesis.
Chemistro certainly appears a lot in his books. Stryker and Cage have personal vendettas against each other. The Purple Man while relatively new to the list did terrible things to his wife.
Related:
Who is Luke Cage?
What do you think? Who on the list stands out most to you?
1) Chemistro
Three men have worn the mantle of Chemistro and all have battled Luke Cage. Chemistro may be Cage's most iconic and reoccurring villain.
Who is Chemistro?

2) Willis Stryker
The former best friend of Cage becomes his bitter enemy as they battle on the roof tops above New York City. Stryker is set to appear as one of the major villains in the Luke Cage Netflix series.
Who is Willis Stryker AKA Diamondback?

3) Mr. Fish
Mr Fish may sound silly but with his immense strength was once able to defeat Cage. No one laughs at Mr Fish!
Who is Mr. Fish?

4) Cheshire Cat
When the secretive, snoopy disappearing villain known as Cheshire appears trouble is bound to follow.
Who is Cheshire Cat?

5) Comanche
Former fellow member of the Rivals, Comanche uses Native American weapons with great proficiency.
Who is Comanche?

6) Shades
Former fellow member of the Rivals now a bitter foe. Shades receives upgraded super weapons in part to battle Cage.
Who is Shades?

7) Cockroach Hamilton
A street enforcer whose gun carries a special punch
Who is Cock Roach Hamilton?

8) Spear
Armed with a special weapon the Spear is out for vengeance on one of Cage's closest friends and allies.
Who is Spear?

9) Moses Magnum
The corrupt arms dealer who never fails to leave a wake of violence and death where ever he goes. Cage once seemingly killed the arms dealer but he did not stay dead for long.
Who is Moses Magnum?

10) The Purple Man
While all the men on this list are bad, only the Purple Man can said be pure evil. He tortured Luke's wife Jessica Jones and that is something Luke will never forgive.
Who is the Purple Man?
