There was a box that was opened by a group of chinese smugglers. The box called itself a breath of fresh air. Once opened the box released a gas or an airborn agent of some kind and the gangsters began seeing themselves as monsters. Previously men were found that had been exposed that literally torn each other apart.
Agent May was also exposed and saw a ghost like figure walk past.
What is Box? or maybe the real question is What was in the box?
It seems clear that the show wants to add supernatural elements to the MCU in part to tie into Doctor Strange and the Ghost Rider addition to the show.
Jeb Whedon was asked at the Premiere about what was in the box and he said its something along the lines of the supernatural elements, "Something we can't tell you, but something along those lines." What can be gleaned from this is that its supernatural and an important subplot that the show will continue to explore.
Is there anything like this in the comics.
Theory One - The Devil's Breath
One thing that jumped to my mind was the Devil's Breath agent that was used by Spider-Man Villain Mister Negative to kill various gangsters. The Devil's Breath would kill anyone of a certain blood line making it a perfect weapon to use against a familial organization like the Maggia Crime Family. Mister Negative later programs it through blood to kill Spider-Man.
The box though did not seem to work like the Devil's Breath at all.
Theory 2 Another Spirit of Vengeance:
One though is that another Spirit of Vengeance was in the box and perhaps now May will gain supernatural powers from it. My reasoning here is that the show keeps promoting Spirit of Vengeance even though the Ghost Rider they are using does not actually use a Spirit of Vengeance. He uses a spirit from a dead serial killer uncle. It is perfectly possible that in the show they have altered this and Robbie Reyes is connected to an actual Spirit of Vengeance.
If it was a Spirit of Vengeance it would help tie the Box to the Ghost Rider and also help explain what he is. It would also tie the Agents to the Ghost Rider with another connection.
Other Magical Items?
Right now I'm drawing a blank as a magical Marvel item that works like this. Let me know if you can think of anything in the comments and I will credit you as a source.
Doctor Strange, Ghost Rider, and Mephisto connections?
There are three characters with supernatural origins that are said to have a big impact on stories throughout the MCU and likely the box what ever is has a connection to one of them. We are talking about Mephisto, Doctor Strange and of course Ghost Rider.
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